Something crash lands on Earth. Everyone goes home from the Super Space-Time Tournament, but Chronoa, Vegeta, Gohan, Piccolo, and Xeno Trunks wait for Goku to wake up. Chronoa attempts to send them to Earth, but it is gone. Shocked, they go to King Kai's planet, but are greeted by Majin Ozotto, who explains that he ate King Kai and his companions, plus everyone and everything on Earth. Now he aims to eat more gods and attacks Chronoa. The others defend her and fight him with Goku and Vegeta using Super Saiyan Blue, Xeno Trunks using Super Saiyan God, and Gohan using Mystic Form, but he quickly absorbs Piccolo and Gohan. When they damage him, he reveals he gained regeneration from absorbing Buu, plus his detached parts can shapeshift into anyone he absorbed, which he demonstrates with Android 17 and 18. He merges with his duplicates and his power skyrockets. Realizing the battle is hopeless, Chronoa teleports herself, Goku, Vegeta, and Xeno Trunks away.

Chronoa explains that Majin Ozotto is a notorious criminal the Time Patrol had been tracking. Ozotto attacks the Elder Kai, having already absorbed Supreme Kai and Kibito, but is interrupted by Xeno Goku and Vegeta. He transforms into Baby and battles them, then has duplicates transform into Frieza and Perfect Cell to battle them. Chronoa's group goes to Namek, but all the Namekians have already been absorbed. They find another Ozotto preparing to consume the planet and challenge him. After Xeno Goku and Vegeta defeat the duplicates, the intrigued Ozottos reveal their desire to absorb everyone to have all their powers and invites both groups to the Ozotto Mansion. They teleport away, leaving invitation cards behind.

Joined by Xeno Goku and Vegeta, the group goes to the Ozotto Mansion, but makes Chronoa stay behind to not risk her. They blast the mansion, but it is unaffected. Ozotto's voice challenges them to split up and enter 5 different entrances. If they find and defeat the real Ozotto, everyone he ate will be freed. Goku finds and battles an Ozotto duplicate using Ultra Instinct; the duplicate changes to Turles, Bojack, and Meta Cooler and they are evenly matched. Vegeta finds a duplicate who changes to Super Janemba's form. After giving Vegeta a beating, the duplicate says he is too weak to be a meal and would rather eat Goku. Enraged, Vegeta uses Super Saiyan Blue Evolved and blasts him with Final Flash. Meanwhile, Gohan wakes up in a pod and finds Goten, Trunks, and others unconscious in pods. As he struggles to break free, Ozotto taunts him and explains that they are all inside his body.

Ozotto taunts Gohan by hurting Goten and Trunks, but when he threatens Videl, Gohan explodes with rage, breaks free from his pod, and attacks Ozotto. After defeating their opponents, Xeno Trunks, Xeno Goku, and Xeno Vegeta contacts each other and realize they cannot contact Chronoa. Goku and Vegeta break into the area where Gohan and Ozotto are fighting after killing the other counterparts of Ozotto, but Ozotto uses the distraction to reabsorb Gohan, and his power skyrockets. With little options, Goku and Vegeta use the Potara to fuse into Vegito. Vegito uses Super Saiyan Blue Kaio-Ken and obliterates Ozotto, causing a heavily injured Gohan to reappear, just before he separates. As Goku and Vegeta check on Gohan, he warns them that they are inside Ozotto. As he says this, the entire mansion morphs into a "Giant Fat Form" Ozotto. Meanwhile, Xeno Trunks, Goku, and Vegeta are threatened by several duplicates of past villains.

An Ozotto seizes Chronoa. After defeating the villain duplicates, Xeno Trunks, Goku, and Vegeta find Ozotto strangling Chronoa, then sealing her in a pod. He attacks them with tentacles, then an army of duplicates while gloating that he now has power over time, but he still wants more. Goku, Vegeta, and Gohan are attacked by tentacles, but Hearts and Lagss show up to help. They start freeing unconscious people from pods, but have to fight off Ozotto duplicates. Hearts detects Ozotto has a hidden, vulnerable organ and the outer wall. After Hearts clears the way of duplicates, Vegeta uses Super Saiyan Blue Evolved, flies to the wall, and uses Final Explosion to blow a hole in it. Goku flies out of the hole in "Giant Fat Form" Ozotto's stomach with an unconscious Vegeta and prepares to face him with Ultra Instinct. Meanwhile, Aeos becomes aware of what is happening.

Goku uses Ultra Instinct to dodge "Giant Fat Form" Ozotto's attacks and counterattack. Ozotto is eager to gain his powers and summons an army of duplicates. Xeno Goku, Vegeta, and Trunks continue to fight duplicates. One duplicate turns into Chronoa and uses her time powers, but Xeno Goku frees the unconscious Chronoa from her pod, making her duplicate disappear as Ozotto rages against losing his time powers. Hearts and Lagss carry all the unconscious prisoners out of Ozotto's body. Goku eliminates the duplicates and uses the Dragon Fist to destroy Ozotto. As Goku sees that Chronoa, Xeno Goku, Vegeta, and Trunks are safe, he passes out from exhaustion. Aeos appears and congratulates Goku. Ozotto's remnants slowly regenerate and try to escape, but Aeos traps him in a jar. She then uses the Super Dragon Balls to restore all the destroyed planets and return everyone home.