Dr. Drew treats people who are struggling with addiction.

The patients experience withdrawals.

After being diagnosed with both severe withdrawal and acute panic, Deanna returns to the clinic in stable condition. On Day 3, the patients deal with powerful emotions brought out during Process Group, including suicidal feelings that at least three of the patients indicate they have felt. Drewbee's father, Jeff, himself a recovering addict for 17 years, meets with Dr. Drew and Bob Forrest about his codependency with his son. Dr. Drew and relationship therapist Simone Bienne speak with Erika and her boyfriend, Stefanos, about how his drug use is harmful to her recovery. After Erika exhibits suspicious behavior, she is given a drug test, which yields positive results.

Continuing from the previous episode, the staff determine that Cymbalta Erika was given caused her positive drug test results, and created elevated serotonin levels that caused her unusual behavior. In Process Group, Cinammon expresses anger at her mother, who tells her she should be with her family instead of in rehab, but Erika's response to this leads to a conflict between the two. Michael talks about his regret over giving up tae kwon do. An agitated Eric talks to Drew about the feelings of betrayal he harbors toward his mother, also a recovering addict, who left the country when he was 16. Dr. Drew expresses concern over Michael and Ashleigh's inability to expressing their emotions, which he says will threaten their ability to remain sober. Ashleigh's irritation with how the others treat their surroundings leads to a fight with Eric during a Hollywood Hills hike on Day 7.

Continuing from the previous episode, Eric and Ashleigh to argue over household cleanliness after their hike on Day 7. While discussing fear with Shelly during Morning Meditation on Day 8, Cinammon, when asked about returning to performing in clubs, denies that alcohol is a trigger for her, and says that her career is more important than her sobriety. Erika's irritation with Cinammon's boisterousness and the attention she feels she draws to herself leads to an argument in Process Group, though they later make amends. On Day 9, Cinammon expresses feelings of deep guilt over throwing away a baby that was born to her when she was four months pregnant.

On Day 10, the patients begin to improve as they approach the midpoint of their stay at the clinic, though Drewbee acts agitated and paranoid from the others, causing conflict that Dr. Drew feels is caused by his continued withdrawal from drugs. Michael goes to a tae kwon do cast in order to reconnect with one of his past passions, while the others go to an Alcoholics Anonymous meeting. Eric and Drewbee leave the meeting, which leads to a tense confrontation with other people on the street and later a heated exchange between him, Heather and Cinammon back at the clinic, after which Eric decides to leave the clinic.

Continuing from the previous episode, Bob finds Eric wandering Pasadena and brings him back to the clinic, but his apology and discussion over the event leads to a fight with Heather on the night of Day 10 and Deanna during Process Group on Day 11. Deanna also reacts to the release of Angel, the father of her son, from prison, and his questions over her fidelity to him while he was in prison. Drew has a one-on-one with her regarding the sexual abuse she suffered as a child, and speaks to Eric and his mother over their history. On Day 12, the group is taken to a dog park, where they speak to a motivational speaker who talks about how his work rescuing dogs helped him recovery from addiction, during which Ashleigh suffers a seizure.

Continuing from the previous episode, on-set medics and the cast react to Ashleigh's alcohol withdrawal seizure. In Process Group on Day 13, Deanna mentions the flashbacks to being gang raped at gunpoint by six men when she was a drug dealer. Ashleigh talks about witnessing her sister, who is 19 months her junior, being molested. The staff are particularly concerned about the enabling environment that Drewbee and Michael will return to. Drew talks to Erika, who is upset at the prospect of not having family present at the upcoming Family Weekend. Cinammon tries to repair her relationship with her father, Mario, a recovering addict and former gang member, who conceived her when he was 16, and was not a substantial presence in her life. Drew and Bob speak with Drewbee about his father's co-dependency, and to his parents, who react to Drewbee's refusal to go to sober living.

On Day 15, Family Weekend begins, during which the patients' families introduce themselves to the group and give testimonials about their history of dealing with addiction. Deanna's mother is confronted over her unsympathetic response to Deanna's past rape; Cinammon and her loved ones are told she must stay in Pasadena for three months to continue her recovery. Ashleigh reveals to her mother the child molestation that Asleigh and her sister suffered as children. Cinammon's father worries about the dangers of her relapsing after rehab, but Cinammon is infuriated when he himself does so after Family Weekend ends. Drewbee continues to refuse to submit fully to the program, despite his parents' efforts, and on Day 16, he walks out of the clinic.

Continuing from the previous episode, Drew takes a walk with Drewbee outside the clinic, and returns with him. As the patients discuss their aftercare plans on Day 17, Erika breaks up with Stefanos. On Day 18, to illustrate that moderation does not work, Drew introduces the patients to guest speakers Audrey Kishline and Sheryl Maloy. The patients are also tasked to address the legal and financial "wreckage of their past", during which Bob accompanies Erika to Stefano's apartment for her things. After Drewbee again leaves the clinic, Drew and Dr. Sharp, believing he has an irreversible mental problem stemming from his prior head injuries, have him transferred to a hospital for a psychiatric hold.