Matt Murdock, whilst dealing with his own personel problems, meets a young woman who knows he's Daredevil, is a virgin and has a baby. She was saved by Daredevil earlier that day from some thugs, and she claims that angels told her his secret identity, the child is Christ reborn and that he must protect the child. She then gives him the baby and disappears.

Black Widow arrives a Matt Murdocks apartment finding it in disarray while taking care of a baby. He convinces her to take care of it for a short while while he goes to the office to investigate the babies true origins. At the office he meets a man who claims to be part of an organization that protects the world from the Anti-Christ, and says that is what the baby is. Matt does not know what to believe, but the man gives him a cross leaves him to make his own choice. After much thought, Daredevil gets the baby from Black Widow and throws it off a roof, and then Black Widow saves it and takes it with her. He then returns home, feeling conflicted. Then Karen knocks on his door and reveals to him that she has AIDS

Foggy Nelson has been arrested for rape and murder one, and his mother refuses to help him, causing Matt to quit. While trying to cool his head, Daredevil stops a mugging, but it turns out to be a trap and he was knocked unconcious. Back at Matt's apartment the man from Matt's office is talking to Karen, telling her that she is HIV positive because misfortune follows the child Matt was taking care of and will continue to do so. Daredevil wakes up in an empty room and hears a sound which pains him. Then a man with a demonic apperance comes in and begins telling him things. Not caring what he has to say Daredevil, breaks out and runs out in the middle of the street with a truck heading towards him.

Daredevil is saved from being run over by Black Widow who is still taking care of the baby. However, Daredevil is confused and still believes the baby is evil, so he grabs it and throws himself off the building. He is not thinking straight and stops his fall and makes his way to the church where his mother is and passes out. When he wakes up he converses with his mother and she helps deal with his crisis of faith. He then talks to Karen, who tries to convince him to let her take care of the baby, but he remembers that he never told her about the baby and realizes the organization has gotten to her. When she tries to convince him that the baby is evil and it is responsible for her problems, Matt says it's not the baby's fault, but hers, and she leaves in tears. Then we flash to Bullseye accepting a deal to find the baby and cause as much damage where it is found and whoever was hiding it.

Daredevil takes the cross he was given to Doctor Strange to see if it has any magical properties or connections, but none are found. However, it did contain a drug that makes one highly susceptible to suggestion and unable to reason logically. They then summon Mephisto to see if there are any signs of the Christian apocalypse. He says there are none and that Daredevil should check on his mother. When he gets back to the church, everybody except his mother is dead. Bullseye then attacks him after making numerous references to J.D Salinger's Catcher in the Rye. Bullseye gets the advantage, but Karen arrives and tries to trade the baby for Daredevil's life. However, the baby is a fake, and so they give him the real one, but before Bullseye leaves, he tosses Daredevil's billy club at him but Karen jumps in the way saving Matt's life at the cost of her own her last words were "I'll miss you".

Matt is angry and depressed, contemplating suicide, but decides to hunt down the man responsible for Karen's death, the man who hired Bullseye. After some persuasive questioning he knows where to find him. When he gets there he fights men pretending to be the Hand. Then he climbs up the elevator shaft which is filled with torchered souls, including a Karen look-a-like, but it does have the same heartbeat as her. He continues making his way through the building, revealing the truths of the oddities experienced in recent days. Finally, He gets to the top and meets the man responsible for everything; Mysterio.

It is revealed the one responsible for the entire conspiracy is Mysterio. Before Daredevil can beat him senseless, Mysterio reminds him that he has the baby and it is inside an airtight chamber, with twenty minutes to live. He then begins to ramble on about all his accomplishments and how the world has not given him the recognition he deserved. The reason for his most recent ploy is revealed to be a tumor, and it was killing him, so he wanted a dramatic demise. He felt that Daredevil was like him, a second stringer and a worthy foe. So he created a scenario that would undo him. He revealed how he faked the virgin pregnancy and the girl's vision, how he drugged Foggy and framed him for murder and faked Karens positive HIV results. Daredevil no longer wants to listen, so he deactivates Mysterio's suit, but doesn't kill him like Mysterio wants and Mysterio kills himself. Daredevil then finds the baby and leaves the building.

The issue begins on the day of Karen Page's funeral and many are in mourning, but none more so than Matt. He has no words to express his sorrow at her funeral. In her will she left him a large sum of money on the condition he will spend it on himself. Later, he meets Spider-Man on the Brooklyn Bridge, and Spider-Man tries to console him with the experience of his own loss, and it helps. Matt then goes to Natasha's place and explains what happened, and asks for her forgivness for his foolishness, which he recieves. Later in the day he and Foggy go to the old lot where he used to live and Matt says they are going to open their own law firm using the money from Karen. The next morning, Matt is at the hospital and is told that the baby is going to be adopted, he is given the opportunity to name her and he decides on Karen.