A one-punch attack in the street leaves a man with a potentially devastating head injury, and trauma team leader Richard quickly realises he needs to perform emergency surgery on a bleed inside his brain. A young man arrives with multiple broken bones and suspected internal injuries following a motorbike accident, while a factory worker hopes the team can save his arm after a horrific accident with a circular saw.

A mother of one suffers a ruptured brain aneurism, leaving Dr Nayak just minutes to stop the bleeding. In resus, a patient's heart stops multiple times while Dr Mandava battles to save his life. A 17-year-old girl is critically injured in a car crash. As her parents race to her side, trauma leader Dr Hall works to identify her injuries and get her to emergency surgery.

Trauma team leader Julie Norton battles to save two patients whose lives hang in the balance. Father of four Ian is rushed in after suffering a cardiac arrest, while another man is bleeding so heavily he risks losing his entire circulatory system. Meanwhile, Ken has fallen from a roof onto a skip, leaving him with a gaping wound to his thigh and potentially life-threatening injuries to his pelvis and spine, and Dr Nayak helps Michael, who has suffered a severe stroke.