The desert in the U.S. southwest is the natural habitat of the Road Runner, a high-octane, cartoon bird who runs so fast on the desert's roadways that he leaves a trail of flame or causes pavement to ripple, distort, or roll up like a carpet. This speedy bird is unrelentingly chased by a hungry coyote named Wile E., who, though believing himself to be a genius, repeatedly fails to catch the Road Runner with his endless supply of ACME Corporation gadgets, weapons, and other paraphernalia. Episodes of this television series contain three theatrical cartoons, one with the Road Runner and Wile E. Coyote, one with Tweety Bird and Sylvester Cat, and one with other characters from Warner Brothers' cartoon classics.

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