The film centers on Howard F. Howard, an overweight everyman. Engaged to Beverly, the woman of his dreams, Howard has one problem - an overactive fixation with The Three Stooges. Everywhere Howard goes, he sees Moe Howard, Larry Fine and Curly Howard intruding on his life. Determined to overcome his fixation, Howard and Beverly prepare for their wedding. But on his way to the ceremony, Howard descends into Stoogemania and finds himself walking into the city streets with other Stoogemaniacs. His only hope is commitment to the Stooge Hills sanitarium, under the care of a renowned psychologist, until the inmates take over the asylum on graduation day.

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