The PFL 10 mixed martial arts event for the 2022 season of the Professional Fighters League will be held on November 25, 2022, at the Hulu Theater in New York City, New York, United States. This will be the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. The event also will also mark the organization's first pay-per-view card, being available on ESPN+ PPV.

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