Charles, an attorney, and Helen, his devoted wife, seemed to have everything – money, a beautiful mansion – the American Dream. However, as Helen prepares to celebrate their 18th wedding anniversary, her life takes an unexpected twist when she comes home to find her clothes packed up in a U-Haul van parked in the driveway. Charles is divorcing her and kicks her out. Helen moves in with her grandmother Madea, an old woman who doesn't take any lip from anyone. Madea helps Helen through these tough times by showing her what is really important in life. Helen is forced to rediscover love, life and religion on her pursuit for happiness.

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